The Research Center for Materials-Driven Regeneration (MDR) is a partnership between Eindhoven University of Technology, Maastricht University and Utrecht University, University Medical Center Utrecht and the Hubrecht Institute. The interdisciplinary team of researchers within the MDR consortium aims to focus on the research and development of new, intelligent materials that stimulate the regeneration of damaged or diseased tissues and organs. Three research flagships are defined according to hierarchical levels of increasing length scale and structural complexity.