NUANCE, Northwestern University's Atomic and Nanoscale Characterization Experimental Center, is leads the SHyNE Resource, a 10-year, $10.5M NSF facilities infrastructure program. NUANCE manages over 100 instruments and tools in support of nanoscale characterization, analysis, and fabrication for over 1000 unique users from 145 faculty groups in 35 departments across Northwestern. As the Midwest node of the NSF's National Nanotechnology Coordinated Infrastructure (NNCI) network, Soft-Hybrid Nanotechnology Experimental (SHyNE) Resource provides operational support to 5 other open-access research facilities (IMSERC, NUCAPT, SQI, Cohen XRD, PLD) at Northwestern and the Pritzker Nanofabrication Facility (PNF) at University of Chicago. Through these enhanced outreach efforts, NUANCE and SHyNE annually works with over 200 external researchers from regional academic, non-profit, government, and commercial/industrial organizations.