XL-protein GmbH Details

XL-protein develops and commercializes its proprietary PASylation® technology to extend the plasma half-life of biopharmaceuticals. The genetic fusion (or chemical conjugation) with conformationally disordered ...
XL-protein develops and commercializes its proprietary PASylation® technology to extend the plasma half-life of biopharmaceuticals. The genetic fusion (or chemical conjugation) with conformationally disordered amino acid sequences composed of the three small residues Pro, Ala, and/or Ser ('PASylation') provides a simple way to attach a solvated biopolymer with large hydrodynamic volume to a therapeutic protein or peptide. This polypeptide adopts a bulky random coil structure, which significantly increases the size of the biopharmaceutical. By this means the typically rapid clearance of the biologically active component via kidney filtration is retarded by 1-2 orders of magnitude, depending on the length of the PAS tag. Compared with other strategies to prolong the plasma half-life of biologics the PASylation technology provides numerous advantages.
Employees
HQ
+49 8161 5373090
Location
Freising, Bavaria
Revenue
$1.4M

Technologies

Tag Management
Payments
Load Balancers
E-commerce Platforms

Notable Alumni

Alexandra Lensch
Senior Manager Regulatory Management
Evonik

Employees

Team Leader R&D
Geschäftsführer
Chairman & Founder
Chief Executive Officer

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